Kongkai Zhu Selected Research

Enzymes

4/2023	PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1.
1/2023	Arginine Methyltransferase 5 (PRMT5) Inhibitors with 3-(1H-benzo[d]imidazol- 2-yl)anilines Core Identified by Virtual Screening and Biological Evaluation.
12/2018	Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors.
12/2018	Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations.
3/2016	Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.
10/2015	Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening.
1/2013	Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Kongkai Zhu Research Topics

Disease

16	Neoplasms (Cancer) 04/2024 - 01/2013
4	Carcinogenesis 01/2019 - 02/2014
3	Lymphoma (Lymphomas) 02/2019 - 11/2014
2	Leukemia 02/2019 - 03/2016
1	Hearing Loss (Hearing Impairment) 04/2024
1	Ovarian Neoplasms (Ovarian Cancer) 04/2023
1	Thrombosis (Thrombus) 01/2022
1	Hemorrhage 01/2022
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Pathologic Processes 10/2020
1	Glioblastoma (Glioblastoma Multiforme) 12/2018
1	Cardiomyopathies (Cardiomyopathy) 12/2018
1	Hepatocellular Carcinoma (Hepatoma) 08/2018
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018
1	Vascular Diseases (Vascular Disease) 10/2015
1	Alopecia Areata 10/2015
1	Infections 09/2014
1	Clostridium Infections 09/2014
1	medullary Thyroid cancer 02/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2013

Drug/Important Bio-Agent (IBA)

7	EnzymesIBA 04/2023 - 01/2013
5	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 04/2023 - 01/2013
5	Arginine (L-Arginine)FDA Link 04/2023 - 01/2013
4	MethyltransferasesIBA 02/2019 - 11/2014
3	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2019
2	Polycomb Repressive Complex 2IBA 01/2020 - 11/2014
2	Lysine (L-Lysine)FDA Link 03/2016 - 10/2015
2	Histone MethyltransferasesIBA 03/2016 - 10/2015
2	Histones (Histone)IBA 03/2016 - 02/2014
1	PlatinumIBA 04/2024
1	PeroxidasesIBA 04/2024
1	Glutathione (Reduced Glutathione)IBA 04/2024
1	Cisplatin (Platino)FDA LinkGeneric 04/2024
1	Paclitaxel (Taxol)FDA LinkGeneric 04/2023
1	Phosphopyruvate Hydratase (Enolase)IBA 04/2023
1	aniline (aniline hydrobromide)IBA 01/2023
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2021
1	CarbohydratesIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Glycoside Hydrolases (Endoglycosidases)IBA 01/2021
1	BenzopyransIBA 01/2021
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 10/2020
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 09/2020
1	Histone Deacetylase InhibitorsIBA 07/2019
1	coumarinIBA 07/2019
1	AlkaloidsIBA 01/2019
1	Nuclear Proteins (Protein, Nuclear)IBA 12/2018
1	CytokinesIBA 12/2018
1	LipopolysaccharidesIBA 12/2018
1	Donepezil (Aricept)FDA LinkGeneric 08/2018
1	Tacrine (Cognex)FDA Link 08/2018
1	ArsenicIBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	Gefitinib (Iressa)FDA Link 01/2018
1	ErbB Receptors (EGF Receptor)IBA 01/2018
1	AstemizoleIBA 11/2014
1	Anti-Bacterial Agents (Antibiotics)IBA 09/2014
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 02/2014
1	Transcription Factors (Transcription Factor)IBA 02/2014
1	cabozantinibIBA 02/2014
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2014

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 04/2024 - 07/2019
2	Therapeutics 11/2014 - 02/2014
1	Oral Administration 04/2024
1	Photochemotherapy (Photodynamic Therapy) 09/2020
1	Intraperitoneal Injections 12/2018